Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides.
نویسندگان
چکیده
Protein tyrosine phosphatases (PTPs) are cysteine-dependent enzymes that play a central role in cell signaling. Organic hydroperoxides cause thiol-reversible, oxidative inactivation of PTP1B in a manner that mirrors the endogenous signaling agent hydrogen peroxide.
منابع مشابه
A chemical model for redox regulation of protein tyrosine phosphatase 1B (PTP1B) activity.
Growing evidence indicates that endogenously produced hydrogen peroxide acts as a cellular signaling molecule that (among other things) can regulate the activity of some protein phosphatases. Recent X-ray crystallographic studies revealed an unexpected chemical transformation underlying the redox regulation of protein tyrosine phosphatase 1B, in which oxidative inactivation of the enzyme yields...
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عنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 18 22 شماره
صفحات -
تاریخ انتشار 2008